Erratum: Gene prioritization through genomic data fusion
نویسندگان
چکیده
منابع مشابه
Kernel-based data fusion for gene prioritization
MOTIVATION Hunting disease genes is a problem of primary importance in biomedical research. Biologists usually approach this problem in two steps: first a set of candidate genes is identified using traditional positional cloning or high-throughput genomics techniques; second, these genes are further investigated and validated in the wet lab, one by one. To speed up discovery and limit the numbe...
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Data integration procedures combine heterogeneous data sets into predictive models, but they are limited to data explicitly related to the target object type, such as genes. Collage is a new data fusion approach to gene prioritization. It considers data sets of various association levels with the prediction task, utilizes collective matrix factorization to compress the data, and chaining to rel...
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UNLABELLED Biomedical literature is traditionally used as a way to inform scientists of the relevance of genes in relation to a research topic. However many genes, especially from poorly studied organisms, are not discussed in the literature. Moreover, a manual and comprehensive summarization of the literature attached to the genes of an organism is in general impossible due to the high number ...
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The abundance of high-throughput biological data, such as microarray or protein-protein interaction assays has lead to a need for new methods of data analysis, that could infer useful information from large amounts of very noisy and indirect measurements. One solution could be provided by data fusion. Data fusion is a relatively recent term describing machine learning methods that can integrate...
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MOTIVATION During the past decade, the new focus on genomics has highlighted a particular challenge: to integrate the different views of the genome that are provided by various types of experimental data. RESULTS This paper describes a computational framework for integrating and drawing inferences from a collection of genome-wide measurements. Each dataset is represented via a kernel function...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2006
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0606-719d